Soooo… I know, thread necromancy and stuff, but I wanted to keep the wishlist clean of my speculations. @Modiphius-Jim has gifted us with a video update on the STA line and about eight minutes in, he mentions to juggle “close to fifty” different products, right now. Maybe he said “fifteen” and not “fifty”. But I hope it’s fifty. 
A lot of are said to be digital products and if Modiphius keeps the current stream of content up, we are to expect both six standalone adventures and six mission brief packs until christmas. For the last couple of months, Modiphius was releasing STA content every other week, releasing a free Mission Brief pack every other of these releases, a standalone adventure being the other release.
Also, if I am teased correctly, there are no less than two print products other than the Lower Decks supplement that are to be released this year. Already saving my latinum. Yet, Jim said probably none of those are expected right now. Let’s see.
The first obvious choice would be to have a supplement on the Picard series. It’s officially finished and we know Modiphius has the license, for there were crew packs already. Also, the third season connected PIC further to DS9, while the presence of “Commander Seven” in all three seasons was a close connection to VOY. Thus, PIC, in a way, is a continuation on STA’s “main” storyline, being the TNG/DS9/VOY era. Yet it might be too obvious and maybe it’s planned for next year or so, to give writers a bit more time to fully include season three.
The next obvious choice would be to have a Discovery supplement for the “future”. The DIS supplement already released specifies a time in it’s title, leaving options open for a second supplement on all the juicy Federation rebuild. Yet, if I were Modiphius, I would again wait on the series to end, as this has already been announced by Paramount/CBS/whoeveridk.
I’m pretty sure I’m not the only one eagerly waiting for a Strange New Worlds supplement. Yet, it took Modiphius three years to obtain the license for Lower Decks and SNW only just started its second season. So, maybe this is already one of the products on Jim’s list, but I wouldn’t expect it this year already.
The last time, I heard Jim telling us about the numbers of products actively in development, was prior to the release of the mini STLs. I would explain the astonishing numbers of products he mentioned then (also 40+ iirc) with all the minis. Which would’ve lead me to the wild speculation that Eaglemoss is out of business and that Modiphius has a history of coming up with mini-intensive tabletop games. Yet, Jim in his last video hinted at other companies having the license for such board games, stressing that Modiphius only is licensed to do character minis, not ship minis. So I don’t think we’ll see ship minis in any context by Modiphius.
So, no clues so far.
My speculation, though, is, that we’ll see another mission compendium. Klingons got a core rulebook and a few standalones and briefs, but not (yet) a mission compendium. And while a year or two ago it was said that there were no plans to release another mission compendium, this might have changed. It would definetly be not expected. 
My second speculation would be a follow-up (in any form) on the Shackleton Expanse campaign setting. It’s Modiphius’ original content and if I remember correctly, hit not too bad on the market (at least it should’ve hit great as it is imho the best supplement of all that have been released). There was many a request for a continuation of the Living Campaign (that is a the base of the Shackleton Expanse book) and while there were four original species in the book, we haven’t seen too much missions / briefs focussing on these species. If I was a writer of the game line, I would pitch such adventures to Jim. I’m pretty sure the writers have done so. So something related to the Shackleton Expanse is high up on my list of expectations (and hopes, btw).
Third, I’m still hoping for a book focussing on Romulans and/or Cardassians. But I don’t think that we will get this, this year. (Yet, if we don’t expect it… it’s a conundrum.)
Fourth and finally, I expect Jim to post a Sloan/Section31 meme as answer to my speculations. As he almost always does. 