Campaign / adventure idea. Starfleet Intelligence sends a ship to the Gamma Quadrant to gather information on Dominion subject worlds. When war breaks out, they are stranded behind the wormhole with orders to conduct a guerrilla campaign against weakly defended Dominion worlds to encourage uprisings. The players are massively outgunned, constantly hunted and must find a way to survive and make it back home.
The ship would likely be an old mothball or civilian vessel, heavily modified for their mission. No cloaking device.
Crew would be Starfleet Intelligence, Marine Raiders, and some 31 Operatives.